According to the temporal-spatial limitation plan in Mashhad, the traffic of heavy and semi-heavy vehicles in certain areas of the city, which mainly includes the central area, is only allowed from 10:00 PM to 9:00 AM. This leads to the replacement of more light cargo vehicles with fewer heavy and semi-heavy cargo vehicles. On the other side, if this limitation plan is not applied, assuming the constant tonnage of the transported cargo, the number of pickups will decrease while the number of heavy and semi-heavy cargo vehicles will increase. However, the decrease in the number of pickups is more than the increase in the number of others. The main purpose of this study is to investigate the results of restrictions and changes in the composition of the cargo fleet from the traffic, environment and safety point of view. For this purpose, version 8.01 of Aimsun traffic simulator software was used. To evaluation of the effectiveness of the mentioned changes, two scenarios were simulated: the existing situation and the condition of not applying temporal-spatial restrictions. The results showed that in the case of applying restrictions, traffic, environmental and safety parameters are improved. But this improvement is very small. This can be seen as the result of two reasons: most of the road network in the central area of Mashhad is low-capacity with an inappropriate level of services, therefore, even if the restriction is not applied, heavy goods vehicles, except in necessary cases, don't willing to cross this area. Also, due to the weak control and the lack of enough smart equipment, the number of violations is high and this plan is not fully implemented.